The use of an AED with mood-stabilizing properties (if the patient is not taking one already) such as carbamazepine, oxcarbazepine, valproic acid and lamotrigine, can be an alternative strategy to a continuation of the anti-depressant drugs during the maintenance phase. These AEDs are known to have a prophylactic effect against the recurrence of depressive and manic episodes in primary mood disorders, but in mood disorders of PWE, this prophylactic effect has yet to be established. This point is particularly relevant in the management of atypical depressive disorders.
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