Benzodiazepines

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The benzodiazepines are widely used as antiepileptic drugs, as well as for anxiolytic, hypnotic and antispastic indications. The main role in epilepsy for diazepam, lorazepam and midazolam is as acute therapy for status epilepticus, acute seizures and in febrile convulsions, and this is covered on pp. 211-13, 218-21. In chronic epilepsy, in addition to clobazam (pp. 123-6) and clonazepam (pp. 127-9), three other benzodiazepines—diazepam, clorazepate and nitrazepam—still have a minor role.

The benzodiazepines all bind to the GABA-A receptors and exert their antiepileptic action by enhancing inhibitory neurotransmission. Differences between the drugs relate to their differential binding at the receptor and their pharma-cokinetic properties. The similarities between the drugs are greater than the differences (Figure 3.12).

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How To Win Your War Against Anxiety Disorders

How To Win Your War Against Anxiety Disorders

Tips And Tricks For Relieving Anxiety... Fast Everyone feels anxious sometimes. Whether work is getting to us or we're simply having hard time managing all that we have to do, we can feel overwhelmed and worried that we might not be able to manage it all. When these feelings hit, we don't have to suffer. By taking some simple steps, you can begin to create a calmer attitude, one that not only helps you feel better, but one that allows you the chance to make better decisions about what you need to do next.

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