Benzodiazepines

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The benzodiazepines are widely used as antiepileptic drugs, as well as for anxiolytic, hypnotic and antispastic indications. The main role in epilepsy for diazepam, lorazepam and midazolam is as acute therapy for status epilepticus, acute seizures and in febrile convulsions, and this is covered on pp. 211-13, 218-21. In chronic epilepsy, in addition to clobazam (pp. 123-6) and clonazepam (pp. 127-9), three other benzodiazepines—diazepam, clorazepate and nitrazepam—still have a minor role.

The benzodiazepines all bind to the GABA-A receptors and exert their antiepileptic action by enhancing inhibitory neurotransmission. Differences between the drugs relate to their differential binding at the receptor and their pharma-cokinetic properties. The similarities between the drugs are greater than the differences (Figure 3.12).

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Do Not Panic

Do Not Panic

This guide Don't Panic has tips and additional information on what you should do when you are experiencing an anxiety or panic attack. With so much going on in the world today with taking care of your family, working full time, dealing with office politics and other things, you could experience a serious meltdown. All of these things could at one point cause you to stress out and snap.

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