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Clonazepam is an alternative to diazepam in stage of early status epilepticus, and there is little to choose between the two drugs. It has a similar onset of action, and a longer duration of action (half-life, 22-33 hours), and may have a lower incidence of late relapse. There is wide experience with the drug in adults and children, although not in neonates, and the drug has proven efficacy in tonic-clonic, partial, and absence status. Clonazepam accumulates on prolonged infusion, with the resulting risk of respiratory arrest, hypotension and sedation—a side-effect profile very similar to that of diazepam (see below). The drug has a negative inotropic action, and as with diazepam thrombophlebitis may occur. There is also a danger of sudden collapse if the recommended rate of injection is exceeded. A continuous infusion of clonazepam is not now recommended because of the dangers of accumulation, and respiratory and cardiovascular collapse.

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Eliminating Stress and Anxiety From Your Life

Eliminating Stress and Anxiety From Your Life

It seems like you hear it all the time from nearly every one you know I'm SO stressed out!? Pressures abound in this world today. Those pressures cause stress and anxiety, and often we are ill-equipped to deal with those stressors that trigger anxiety and other feelings that can make us sick. Literally, sick.

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