Hair Loss Natural Treatment
These side effects should also be mentioned, however briefly. Valproate is associated with many potential adverse reactions. These include fatigue, tremor, hair loss, teratogenic effects, polycystic ovarian disease, idiosyncratic liver and hematopoetic reactions, and weight gain.6 The patient in this case experienced serious weight gain. Her weight quickly ballooned by more than 30 kg and has not diminished over the succeeding decade. Nonetheless, her sensible opinion is that the benefits of seizure control far outweigh the detriment of obesity. Usually this decision must be made by the patient, who ultimately bears the burden both of the illness and the treatment.
Another unusual side-effect of valproate is its propensity, rarely, to cause hair loss, or change in colour or more usually curling of hair. Some degree of hair loss occurs in up to 12 of patients. The mechanism is unclear, but it may be due to the formation of abnormal metabolites. The hair curling can sometimes be profound, and striking changes of appearance (not always unwelcome) may result. It is said that the hair changes reverse if therapy is continued, but in the author's experience this is certainly not true in all cases.
An excellent anticonvulsant for generalized and focal seizures. Recently it has started to be used for nonconvulsive disorders, including migraine prevention and as a mood stabilizer for bipolar disorders. Valproic acid comes in Depakene and Depakote forms. Seizures controlled with this medication include myoclonic seizures, absence seizures, and mixed-type seizures. Side effects include initial transient sedation and abdominal pain (better tolerated with the Depakote form). It may also increase the appetite (causing weight gain), cause some transient hair loss (which improves with zinc supplementation), or cause liver and blood count abnormalities, although this is rare. Hyperammonemia and pancreatic dysfunction have also been reported. In children younger than 3, and especially younger than 2, valproic acid may cause a severe fatal liver disease in a frequency as high as 1 in 300. Many patients taking valproic acid may have an associated carnitine...
There are some specific dilemmas while selecting appropriate AED in WWE. Weight gain and weight loss has been associated with AEDs. Other adverse effects that may limit the use of the drug in WWE are hair loss and excessive hair growth.6 Acceptance of drug-related cosmetic side effects to some extent may also depend on the socio-economic-cultural factors.7 In developing countries cost factors and easy availability of the drug need to be considered in addition to effectiveness for seizure control and cosmetic side effects.
Long-term side effects of AEDs, such as neuropathies, connective tissue disorders, and cerebellar degeneration, can also occur, particularly with chronic use of phenytoin and phenobarbital. In most cases, these effects are not symptomatic, but phenytoin can produce gingival hyperplasia and cosmetic changes that are disturbing, and phenobarbital can produce Depuytren's contractures. In some people, valproate causes weight gain and alopecia, which can be a problem, particularly for young women.
Menkes kinky hair disease, a sex-linked disorder with its gene located on the long arm of the X chromosome, causes a marked reduction of serum copper and serum cerulo-plasmin levels. Patients typically present at 2-3 months of age. The clinical findings consist of mental retardation, poorly pigmented fragile hair, hypotonia, and generalized seizure activity, frequently infantile spasms (48). Milder forms have been described with less or minimal neurologic sequelae the mildest Menkes variant is known as Skin rashes and striking neurologic symptoms with seizures are prominent signs of biotinidase deficiency. Hypotonia, developmental delay, and seizures are presenting features in the neonatal form. In the late-onset type, 1 week to 2 years onset, the most common presenting feature is seizures. The most common seizure type is myoclonus, although generalized tonic-clonic and focal clonic seizures have been described (61). Ataxia and hypotonia are present, as are rash and alopecia. Hearing...
Skin rashes are less common with valproate than with carbamazepine, phenytoin and lamotrigine, and therefore valproate is a reasonable choice for patients with a history of hypersensitivity 25 . The main side-effects are GI upset, nausea, vomiting, tremor, weight gain and hair loss 26 . Tremor and weight gain are dose related. GI upset can sometimes be avoided by using alternative formulations, such as sustained release or sprinkles. Elevated ammonia levels can be seen commonly, affecting 20-50 of patients 26 . In some patients this is well tolerated and not problematic, while in others elevated ammonia can be associated with encephalopathy, triphasic waves and even coma 27 . It is not recommended to monitor ammonia in asymptomatic patients. However, if patients demonstrate encephalopathy, particularly in the presence of asteryxis and or delta slowing on the electroencephalogram (EEG), it is reasonable to check for hyperammonaemia. Carnitine supplementation has been recommended to...
Cockayne syndrome is characterized by paucity of growth with developmental delay loss of subcutaneous fat cold, cyanosed extremities increased pigmented nevi and decreased scalp hair. With increasing cachexia the patient's distinctive facies, enophthalmos, and absent fat are prominent features. Mental retardation and microcephaly with ventriculomegaly and questionable normal-pressure hydrocephalus are present. Hyperto-nicity with various movement disorders and myoclonic jerks is present. Optic atrophy and retinal pigmentary changes occur. The disorder is inherited as an autosomal recessive trait caused by several different mutations on chromosomes 5, 10, 13, and 19. Seizure activity usually has an early onset but can occur initially in adults. Status epilepticus resulting in death has been reported (186, 187).
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