Cortical inhibition

From clinical experience with ECT, a third hypothesis may be derived: inhibition of cortical activity, as the major mechanism of ECT (Sackheim et al., 1996), may enhance depressive mood states and may improve seizure control. Since VNS seems to produce rather similar effects as ECT, one may speculate also that VNS increases the inhibitory influences on cortical tone. However, evidence confirming this speculation and replication of the findings from ECT is missing (Hammond et al., 1992«).

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