Alumina Gel Injection Models of Epilepsy in Monkeys

CHARLES E. RIBAK, LEE A. SHAPIRO, LASZLO SERESS, AND ROY A. BAKAY

Epilepsy is a neurologic disorder that has been modeled in many animals, including the monkey. This chapter deals with two types of alumina gel injections that model two different human epileptic disorders. Where alumina gel is injected into the brain determines what type of epilepsy it models. For example, alumina gel injections into sensori-motor cortical regions produce seizures that have been used as a model for posttraumatic epilepsy. Alternatively, when alumina gel is injected into the temporal lobe of rhesus monkeys, complex partial seizures and neuropathologic changes occur which are analogous to those seen in human temporal lobe epilepsy. This chapter will examine each of these two models, beginning with the sensorimotor cortex model.

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